IKKα at the Crossroads of Inflammation and Metastasis
نویسندگان
چکیده
The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumorinfiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKα in prostatic epithelial tumor cells. This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate.
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ورودعنوان ژورنال:
- Cell
دوره 129 شماره
صفحات -
تاریخ انتشار 2007